Zinc Gluconate

About Zinc Gluconate

Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA. It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and with decreased symptom severity.

Although it has been nasally administered for treating the common cold, this route of administration has been associated with some cases of anosmia. Studies show that zinc may be better absorbed in humans in the gluconate form.

Interestingly, zinc supplementation has become a critical intervention for treating diarrheal episodes in children. Studies suggest that administration of zinc along with new low osmolarity oral rehydration solutions/salts (oral rehydration solution), may reduce both the duration and severity of diarrheal episodes for up to 12 weeks.

Zinc gluconate is mainly indicated in conditions like zinc deficiency, and can also be administered in adjunctive therapy as an alternative drug of choice in diarrhea. Zinc is an important mineral found in almost every cell in the human body. It promotes the activity of about 100 enzymes. Zinc deficiency is often associated with an increased risk of infection. When they are used to treat the common cold, zinc supplements may interfere with rhinovirus cleavage or adhesion and may play a role in protecting plasma membranes from microbial toxins and complement.

Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV).